But a provincial official said that it could be an insider attack as one of the guards was still missing.
"An investigation is ongoing to find out if someone from inside has defected to the Taliban and paved the way for this crime," he said.
The attack, in the provincial capital Lashkar Gah, underlined the threat facing Afghan security forces in the opium-producing province, where they struggle to match well-equipped Taliban fighters who now control several districts.
The police killed in the attack had been pulled back from the southern district of Khanshin district which security forces abandoned last year.
"They attacked other policemen with hand grenades and killed all of them. They later took their weapons and ammunition and escaped." he said.
Taliban fighters now control most of Helmand, including areas in Lashkar Gah. British and U.S. forces suffered their heaviest casualties of the war in the province in years of fighting following the removal of the Taliban in 2001.
Afghan security forces now control less than 60 percent of the country, according to U.S. estimates, with the Taliban in control of about 10 percent and the remainder contested between government and insurgent forces.